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Endocrine Abstracts

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ea0011p626 | Neuroendocrinology and behaviour | ECE2006

The influence of a GH receptor antagonist (GHRA) on the relationship between GH and IGF-I in adults with severe growth hormone deficiency (AGHD)

Pokrajac A , Berg CA , Bidlingmaier M , Strasburger CJ , Shalet SM , Trainer PJ

Approximately 50% of patients with severe AGHD (defined by the international consensus criteria, peak GH <3 ng/ml) have a normal age- and gender-related IGF-I. It remains unclear whether in these individuals IGF-I is GH-dependent.We performed a double-blind, randomised, placebo-controlled, cross-over study on the effect of pegvisomant (20 mg daily for 14 days) on the relationship between GH and IGF-I in 3 age-, gender- and BMI-matched cohorts (Norms:...
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ea0011p627 | Neuroendocrinology and behaviour | ECE2006

Can adults with severe growth hormone deficiency (AsGHD) and a low IGF-I be distinguished from those with a normal IGF-I?

Berg CA , Pokrajac A , Bidlingmaier M , Strasburger CJ , Mann K , Shalet SM , Trainer PJ

Approximately 50% of patients with severe AGHD (defined by the international consensus criteria, peak GH <3 ng/ml) have a normal age- and gender-related IGF-I. It remains unclear whether in these individuals IGF-I is GH-dependent. We performed a double-blind, randomised, placebo-controlled, cross-over study on the effect of pegvisomant (20 mg daily for 14 days) on the relationship between GH and IGF-I in 3 age-, gender- and BMI-matched cohorts (Norms: 5 GHD patients with n...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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